We explored the effects of quercetin on cardiac fibrosis, a major concern in cardiovascular diseases. Using an experiment on mice, we administered quercetin after inducing cardiac stress and assessed its impact on heart function and fibrosis. Our findings showed that quercetin significantly reduced cardiac fibrosis and helped reverse cell proliferation caused by stress hormones. This protective effect was linked to its regulation of the SIRT3 signaling pathway. Overall, quercetin presents a promising avenue for addressing heart fibrosis.
Read More
8
Quercetin aids heart recovery post-infarction
Quercetin is a potential therapy for post-infarction NETosis formation.
We examined the effects of quercetin on heart damage following a heart attack in rats. In our study, quercetin was administered just before reperfusion after a blockage in the heart's blood supply.
The results showed that quercetin significantly improved heart function and reduced harmful neutrophil formations. By lowering these formations, we believe quercetin may offer new hope as a protective treatment against heart injuries caused by reperfusion and inflammation.
Read More
9.5
Quercetin improves post-MI recovery
Preventive Administration of Quercetin Promotes Survival and Reduces Adverse Ventricular Remodeling after myocardial infarction through facilitating M2-like macrophage polarization.
We investigated the potential of quercetin, a natural compound found in fruits and vegetables, to prevent challenges after a heart attack (myocardial infarction, or MI). By treating mice with quercetin before inducing MI, we observed significant improvements in heart function, survival rates, and reduced heart damage caused by inflammation and fibrosis.
The study also revealed that quercetin helps shift immune cells toward a healing state, crucial for recovery. This promising research opens the door for quercetin's use in treating cardiac issues related to heart attacks.
Read More
Most Useful Reviews
9
Cardiovascular support
9 people found this helpful
I ordered this long ago but only recently tried it. My endocrinologist suggested bromelain for better food absorption and anti-inflammatory activity. Quercetin strengthens blood vessels and supports the cardiovascular system. I take one to two capsules twice daily with food, and the jar lasts long enough for a complete course.
Read More
9
Preventing disease
3 people found this helpful
This is an excellent supplement for heart health. We use it for both my mother and grandmother, especially after Covid-19, as it's crucial for vascular recovery. Quercetin is a powerful antioxidant, protecting cell membranes and helping prevent cardiovascular disease.
Read More
9
Immunity booster
3 people found this helpful
Quercetin is a powerful immunomodulator and antioxidant I always buy to strengthen my immune system. During the pandemic, it’s especially vital as it defends against infections. Quercetin has numerous benefits, including heart support and accelerated healing. I recommend keeping it in your home for overall health.
Preventive Administration of Quercetin Promotes Survival and Reduces Adverse Ventricular Remodeling after myocardial infarction through facilitating M2-like macrophage polarization.
We investigated the potential of quercetin, a natural compound found in fruits and vegetables, to prevent challenges after a heart attack (myocardial infarction, or MI). By treating mice with quercetin before inducing MI, we observed significant improvements in heart function, survival rates, and reduced heart damage caused by inflammation and fibrosis.
The study also revealed that quercetin helps shift immune cells toward a healing state, crucial for recovery. This promising research opens the door for quercetin's use in treating cardiac issues related to heart attacks.
Read More
9
DBD enhances plaque stability
An integrative approach for mechanistic insights into the atherosclerotic plaque-stabilizing properties of Danggui Buxue decoction.
We examined the impact of Danggui Buxue Decoction (DBD), a traditional Chinese remedy, on atherosclerotic plaques in a mice model. Using a blend of advanced bioinformatics and experimental validation, we discovered that DBD can effectively stabilize these plaques.
Key ingredients like quercetin played a significant role in this process by targeting several important proteins that influence inflammation and lipid metabolism. Our findings suggest that quercetin and another compound, kaempferol, work together to improve heart health by reducing atherosclerotic vulnerability.
Read More
9
Quercetin may protect heart health
Quercetin Reduces the Susceptibility to Cardiac Reperfusion Arrhythmias in Ovariectomized Rats.
We examined how quercetin might protect against heart issues associated with menopause, particularly by looking at its effects on cardiac reperfusion arrhythmias in ovariectomized rats. Over a four-week period, we found that quercetin significantly reduced heart damage and improved mitochondrial function by enhancing ATP production. This suggests quercetin may help manage some heart health risks tied to decreased estrogen levels. While our findings are promising, further research in humans is needed to confirm these effects.
Read More
9
Quercetin protects platelet function
Quercetin inhibits platelet activation and ER-stress mediated autophagy in response to extracellular histone.
We investigated the effects of quercetin (QUE), a natural dietary phytochemical, on platelet toxicity induced by extracellular histones, which can harm our body during critical illnesses.
In our study, we set up experiments to observe how histones trigger platelet activation and the protective influence of QUE. Our findings revealed that QUE successfully reduced platelet activation and protected against stress-induced damage.
This suggests that quercetin could be a promising candidate for addressing platelet-related issues associated with histones.
Read More
9
Quercetin provides protective effects
Dynamic and quantitative assessment of quercetin for cardiac oxidative stress injury prevention using sensitive cardiomyocyte based biosensing.
We developed an innovative biosensing platform to explore how quercetin affects heart cells, especially during cardiac oxidative stress. By testing cardiomyocytes, we found that quercetin can protect against injury caused by oxidative stress, highlighting its potential as a therapeutic option.
However, we also determined a safe concentration limit and noted potential long-term effects on heart cells. This balanced evaluation not only sheds light on quercetin's advantages but also emphasizes the need for careful consideration in its use for cardiovascular health.
I ordered this long ago but only recently tried it. My endocrinologist suggested bromelain for better food absorption and anti-inflammatory activity. Quercetin strengthens blood vessels and supports the cardiovascular system. I take one to two capsules twice daily with food, and the jar lasts long enough for a complete course.
Read More
9
Preventing disease
3 people found this helpful
This is an excellent supplement for heart health. We use it for both my mother and grandmother, especially after Covid-19, as it's crucial for vascular recovery. Quercetin is a powerful antioxidant, protecting cell membranes and helping prevent cardiovascular disease.
Read More
9
Immunity booster
3 people found this helpful
Quercetin is a powerful immunomodulator and antioxidant I always buy to strengthen my immune system. During the pandemic, it’s especially vital as it defends against infections. Quercetin has numerous benefits, including heart support and accelerated healing. I recommend keeping it in your home for overall health.
Read More
9
Fights allergies
2 people found this helpful
Quercetin is a potent antioxidant and anti-inflammatory agent. It strengthens capillary walls, prevents the production of histamine, and helps treat respiratory diseases like asthma while combating cardiovascular disease and viral infections. It is also beneficial for preventing cognitive decline and skin aging.
Read More
7.5
Immune system boost
526 people found this helpful
Excellent tool! I found Quercetin with Bromelain effective for strengthening my immune system and alleviating allergy symptoms. After taking one capsule daily, I noticed a reduction in my allergies and anti-inflammatory effects by the first week. I'm optimistic about its potential to slow down the ageing process. Thank you for this product!
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Quercetin is a naturally occurring flavonoid that is found in a variety of fruits, vegetables, and grains. Known for its antioxidant properties, quercetin is believed to help combat oxidative stress in the body, which can contribute to various health issues. You can commonly find it in foods such as apples, onions, berries, and citrus fruits, as well as in leafy greens. This makes it a popular dietary supplement among health enthusiasts looking to enhance their overall wellness.
Beyond its antioxidant capacity, quercetin is also being researched for its potential anti-inflammatory effects and benefits for immune support. Some studies suggest that it may help reduce allergy symptoms and improve exercise performance by decreasing muscle fatigue. With its wide range of potential health benefits, quercetin is often marketed as a natural remedy for various ailments, although it’s essential to consult a healthcare professional before starting any new supplement regimen to ensure its safety and effectiveness for your specific needs.
Quercetin is a flavonoid found in various fruits, vegetables, and grains, and it has gained attention for its potential health benefits, particularly concerning cardiovascular health. Some studies suggest that quercetin may help lower blood pressure, reduce LDL cholesterol oxidation, and improve overall endothelial function, which can contribute to better heart health. The anti-inflammatory and antioxidant properties of quercetin are thought to play a role in these benefits, making it a substance of interest for those looking to manage or prevent cardiovascular disease.
However, while there is some promising research, the evidence is not yet conclusive enough to recommend quercetin as a sole treatment for cardiovascular disease. Most of the studies conducted so far have used concentrations of quercetin that are higher than what one would typically consume through diet alone. So, while incorporating quercetin-rich foods, like onions, apples, and berries, into your diet could be beneficial, it's essential to consult a healthcare provider before considering quercetin supplements or making significant changes to your health regimen.
Users report varying timelines for experiencing the benefits of Quercetin when used to support cardiovascular health. Many individuals have noticed positive effects within the first week of use, particularly in terms of reducing inflammation and improving overall health (e.g., Read Review). Some users, particularly those managing specific conditions, have noted significant improvements, such as reduced cholesterol levels and enhanced blood flow, after several weeks of consistent use (e.g., Read Review).
Overall, while some users experience rapid changes in their health, others suggest a more gradual accumulation of benefits over time. It's evident from user reviews that consistent use appears to lead to the best outcomes in cardiovascular support and overall wellness, with many recommending ongoing use rather than seeking immediate results (e.g., Read Review). For those considering Quercetin with Bromelain, incorporating it as part of a long-term health plan seems to be the most productive approach.
Quercetin has garnered attention in recent research for its potential benefits in cardiovascular health. A study demonstrated that quercetin effectively helped manage heart issues related to inflammation and oxidative stress, particularly its combined use with curcumin in treating atherosclerosis. The results indicated significant reductions in harmful stress in human vascular smooth muscle cells, suggesting its promise as a treatment for chronic inflammatory cardiovascular diseases [2]. Additionally, quercetin has shown effectiveness in various heart-related challenges, such as improving heart function post-heart attack and reducing cardiac fibrosis, emphasizing its protective qualities albeit with a call for further human studies [3], [11].
Moreover, evidence suggests that quercetin's effects may be enhanced by gut bacteria, which play a crucial role in its metabolism, further linking it to cardiovascular benefits [8]. Overall, while there's ample preliminary evidence showcasing quercetin's heart health advantages and its mechanisms, more human-centered studies are needed to solidify its potential as a widely accepted supplement for cardiovascular disease management.
Users report a wide range of improvements in symptoms after taking Quercetin, particularly regarding immune support and cardiovascular health. Many individuals have noted a reduction in allergy symptoms and inflammation, with some experiencing relief within just a week of use (e.g., Read Review, Read Review, Read Review). Users have also reported significant benefits for respiratory health and digestive issues. For example, others with chronic conditions, such as hyperlipidemia, have seen notable improvements in cholesterol levels and blood flow after integrating Quercetin into their regimen (e.g., Read Review).
Several reviewers highlight the antioxidant properties of Quercetin, stating that it has aided in overall health maintenance by protecting cell membranes and improving heart function (e.g., Read Review, Read Review, Read Review). Many have experienced enhanced health outcomes with ongoing use, recognizing its role as a comprehensive supplement for various health concerns. While individual results can vary, the consensus among users is that consistent use of Quercetin with Bromelain can lead to meaningful improvements across multiple health dimensions.
Users report that combining Quercetin with Bromelain enhances its effectiveness, particularly in supporting cardiovascular health and reducing inflammation. Many have noted that this combination not only strengthens blood vessels but also aids in preventing cardiovascular disease by promoting improved blood flow and reducing cholesterol levels (e.g., Read Review, Read Review). Some users emphasize that Bromelain's role in enhancing Quercetin absorption is crucial for maximizing its cardiovascular benefits, stating that they have experienced tangible improvements in heart health when taking these supplements together (e.g., Read Review, Read Review).
Additionally, many users also integrate Quercetin with other supplements, such as Vitamin C, to amplify its antioxidant effects and enhance cardiovascular protection (e.g., Read Review). Overall, the consensus among users is that the combination of Quercetin with Bromelain, and potentially other supplements, can lead to significant improvements in cardiovascular health, immune function, and general well-being (e.g., Read Review, Read Review).
Based on user reviews, the right dose for Quercetin in treating cardiovascular disease varies slightly but generally centers around taking the supplement one to two capsules twice daily with meals. One user mentioned that their endocrinologist advised them to take one to two capsules twice daily for the best results Read Review. Additionally, another review suggested that two capsules taken before meals supported cardiovascular health effectively Read Review.
Overall, many users emphasized the importance of maintaining consistent dosing to achieve the desired cardiovascular benefits, particularly when paired with bromelain for enhanced absorption. It is also noted that regular intake helps strengthen blood vessels and prevent cardiovascular disease Read Review. While specific dosages can vary, users seem to converge on a regimen of twice-daily use as optimal for heart health.
7.5
Immune system boost
526 people found this helpful
Excellent tool! I found Quercetin with Bromelain effective for strengthening my immune system and alleviating allergy symptoms. After taking one capsule daily, I noticed a reduction in my allergies and anti-inflammatory effects by the first week. I'm optimistic about its potential to slow down the ageing process. Thank you for this product!
9
Cholesterol reduction
33 people found this helpful
As I manage hyperlipidemia and Hashimoto's disease, I started taking Quercetin to reduce inflammation. I’m thrilled to say that my cholesterol has decreased significantly! Quercetin is improving my blood flow and aiding in cardiovascular disease prevention.
7.5
Anti-inflammatory agent
3 people found this helpful
Quercetin and bromelain enhance the immune system and effectively combat viral infections and inflammatory conditions, which can also affect cardiovascular disease. I find this supplement invaluable for my health.
7.5
Allergy symptom relief
142 people found this helpful
I took Quercetin for allergies and as an antioxidant. The capsules are pleasant and easy to swallow. After a week, I experienced relief from allergy symptoms and improved digestion, including reduced constipation. Quercetin strengthens blood vessels and helps mitigate cardiovascular disease risks.
7.5
Effective antihistamine
7 people found this helpful
Having suffered from allergies since childhood, I chose quercetin as a natural remedy. After 16 years, it effectively reduces allergic reactions and inflammation, supporting cardiovascular health by strengthening blood vessels. I take it daily with food, especially during allergy season.
9
Preventing disease
3 people found this helpful
This is an excellent supplement for heart health. We use it for both my mother and grandmother, especially after Covid-19, as it's crucial for vascular recovery. Quercetin is a powerful antioxidant, protecting cell membranes and helping prevent cardiovascular disease.
9
Fights allergies
2 people found this helpful
Quercetin is a potent antioxidant and anti-inflammatory agent. It strengthens capillary walls, prevents the production of histamine, and helps treat respiratory diseases like asthma while combating cardiovascular disease and viral infections. It is also beneficial for preventing cognitive decline and skin aging.
7.5
Immunity boost
3 people found this helpful
Quercetin is a potent antioxidant that protects cell membranes and strengthens small blood vessels, aiding in the prevention of cardiovascular disease. It enhances immune function and is effective for various inflammatory diseases, offering excellent overall health benefits.
7.5
Blood cleansing
72 people found this helpful
Quercetin and Bromelain work effectively together to cleanse the blood and reduce inflammation. Quercetin boosts blood vessel tone and prevents clots, which is crucial for preventing cardiovascular disease. It is recommended to take Quercetin in courses due to potential kidney stress.
9
Respiratory health
63 people found this helpful
I highly recommend Quercetin, as it combats respiratory infections and supports cardiovascular health. Bromelain enhances Quercetin absorption, improving intestinal health and nutrient uptake.
9
Strong antioxidant
1 people found this helpful
I highly recommend Quercetin for heart health, especially after COVID to support vascular repair. It acts as a potent antioxidant, protects cell membranes from free radicals, and is effective against cardiovascular diseases.
9
Natural anti-inflammatory
1 people found this helpful
Most people don't know that quercetin is a natural anti-inflammatory, akin to ibuprofen. It's effective in alleviating many conditions tied to cardiovascular disease, allergies, and even mental health issues. Combining it with Vitamin C enhances its benefits.
7.5
Effective antioxidant
1 people found this helpful
Quercetin with bromelain is an excellent natural remedy that acts as a powerful antioxidant and immunomodulator. It supports immune health, digestion, and reduces inflammation. I have seen significant positive results, and it’s safe with no side effects.
9
Cardiovascular support
9 people found this helpful
I ordered this long ago but only recently tried it. My endocrinologist suggested bromelain for better food absorption and anti-inflammatory activity. Quercetin strengthens blood vessels and supports the cardiovascular system. I take one to two capsules twice daily with food, and the jar lasts long enough for a complete course.
7.5
Heart health support
9 people found this helpful
I take this dietary supplement to meet GMP standards, especially as I’m currently being treated for Covid-19. The doctor advised two capsules twice daily before meals. Quercetin helps with respiratory infections, and bromelain enhances its absorption. Together, they support cardiovascular health.
8
Quercetin and curcumin synergize cardiovascular effects
Dual Modulation of Canonical and Non-canonical TGF-β/ROS/Erk1/2 Pathways: Synergistic Activation of Nrf-2 and Antioxidant Enzymes (SOD1, GPx, HO-1) by Quercetin Loaded in Solid Lipid Nanoparticles and Curcumin in Atherosclerosis Therapy.
We investigated how quercetin, specially prepared in solid lipid nanoparticles, works alongside curcumin to combat atherosclerosis. Using human vascular smooth muscle cells, we treated them with these compounds and observed their effects on inflammation and oxidative stress.
Our results showed that this combination significantly reduced harmful oxidative stress and inflammation associated with a key signaling pathway in cells. This suggests that their synergistic effect could offer a promising new treatment for cardiovascular diseases linked to chronic inflammation.
9.5
Quercetin improves post-MI recovery
Preventive Administration of Quercetin Promotes Survival and Reduces Adverse Ventricular Remodeling after myocardial infarction through facilitating M2-like macrophage polarization.
We investigated the potential of quercetin, a natural compound found in fruits and vegetables, to prevent challenges after a heart attack (myocardial infarction, or MI). By treating mice with quercetin before inducing MI, we observed significant improvements in heart function, survival rates, and reduced heart damage caused by inflammation and fibrosis.
The study also revealed that quercetin helps shift immune cells toward a healing state, crucial for recovery. This promising research opens the door for quercetin's use in treating cardiac issues related to heart attacks.
8
Quercetin reduces cardiac fibrosis
Quercetin Alleviates Cardiac Fibrosis via Regulating the SIRT3 Signaling Pathway.
We explored the effects of quercetin on cardiac fibrosis, a major concern in cardiovascular diseases. Using an experiment on mice, we administered quercetin after inducing cardiac stress and assessed its impact on heart function and fibrosis. Our findings showed that quercetin significantly reduced cardiac fibrosis and helped reverse cell proliferation caused by stress hormones. This protective effect was linked to its regulation of the SIRT3 signaling pathway. Overall, quercetin presents a promising avenue for addressing heart fibrosis.
8
Quercetin effectiveness linked to gut microbes
Gut microbes modulate the effects of the flavonoid quercetin on atherosclerosis.
We discovered that quercetin, a popular flavonoid, can significantly reduce atherosclerosis in mice with a normal gut microbiome. However, this effect was not observed in germ-free mice, indicating that gut bacteria play a crucial role.
The treatment boosted levels of specific compounds linked to the health benefits of quercetin, particularly in conventional mice. These findings suggest that the metabolism of quercetin by gut microbes is essential for its cardiovascular benefits.
References
Ji K, Han M, Yang M, Xu Q, Zhang Y. Integrated meta-analysis and network pharmacology analysis: evaluation of Zhigancao decoction as treatment for diabetic cardiomyopathy. Front Cardiovasc Med. 2025;12:1454647. doi:10.3389/fcvm.2025.1454647
Shamsi M, Mohammadzadeh G, Hatami M, Roshanazadeh M, Noor-Behbahani M, et al. Dual Modulation of Canonical and Non-canonical TGF-β/ROS/Erk1/2 Pathways: Synergistic Activation of Nrf-2 and Antioxidant Enzymes (SOD1, GPx, HO-1) by Quercetin Loaded in Solid Lipid Nanoparticles and Curcumin in Atherosclerosis Therapy. Iran J Pharm Res. 2024;23:e151428. doi:10.5812/ijpr-151428
Wang L, Lin S, Wei Q, Li T, Mo Q, et al. Preventive Administration of Quercetin Promotes Survival and Reduces Adverse Ventricular Remodeling after myocardial infarction through facilitating M2-like macrophage polarization. Int Immunopharmacol. 2025;151:114296. doi:10.1016/j.intimp.2025.114296
Zheng G, Cao X, Jing Y, Wang L, Yan R, et al. An integrative approach for mechanistic insights into the atherosclerotic plaque-stabilizing properties of Danggui Buxue decoction. J Ethnopharmacol. 2025;343:119450. doi:10.1016/j.jep.2025.119450
Domingos AE, Breves CMDC, Boa LF, de Souza IIA, Maciel L, et al. Quercetin Reduces the Susceptibility to Cardiac Reperfusion Arrhythmias in Ovariectomized Rats. Mol Nutr Food Res. 2025;69:e202400284. doi:10.1002/mnfr.202400284
Manikanta K, NaveenKumar SK, Hemshekhar M, Thushara RM, Mugesh G, et al. Quercetin inhibits platelet activation and ER-stress mediated autophagy in response to extracellular histone. Phytomedicine. 2025;138:156386. doi:10.1016/j.phymed.2025.156386
Long X, Tao S, Yang S, Li S, Rao L, et al. Quercetin improves heart failure by inhibiting cardiomyocyte apoptosis suppressing the MAPK signaling pathway. Nan Fang Yi Ke Da Xue Xue Bao. 2025;45:187. doi:10.12122/j.issn.1673-4254.2025.01.22
Kasahara K, Kerby RL, Aquino-Martinez R, Evered AH, Cross TL, et al. Gut microbes modulate the effects of the flavonoid quercetin on atherosclerosis. NPJ Biofilms Microbiomes. 2025;11:12. doi:10.1038/s41522-024-00626-1
Mahyar M, Ghadirzadeh E, Nezhadnaderi P, Moayedi Z, Maboud P, et al. Neuroprotective effects of quercetin on hippocampal CA1 neurons following middle cerebral artery ischemia‒reperfusion in male rats: a behavioral, biochemical, and histological study. BMC Neurol. 2025;25:9. doi:10.1186/s12883-024-04017-z
Mkhize SA, Nthlane RA, Xhakaza SP, Verhaert PD, Baijnath S, et al. Decreased blood pressure with acute administration of quercetin in L-NAME-induced hypertensive rats. Basic Clin Pharmacol Toxicol. 2025;136:e14113. doi:10.1111/bcpt.14113
Lin DW, Jiang YW, Wu C, Zhang H, Li YZ, et al. Quercetin Alleviates Cardiac Fibrosis via Regulating the SIRT3 Signaling Pathway. Cardiovasc Drugs Ther. 2024. doi:10.1007/s10557-024-07658-x
Chen J, Lyu X, Yuan Q, Qin C, Yu H, et al. Dynamic and quantitative assessment of quercetin for cardiac oxidative stress injury prevention using sensitive cardiomyocyte based biosensing. Biosens Bioelectron. 2025;271:117045. doi:10.1016/j.bios.2024.117045
Scalise M, Cianflone E, Quercia C, Pagano L, Chiefalo A, et al. Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids. Mech Ageing Dev. 2025;223:112007. doi:10.1016/j.mad.2024.112007
Goshovska Y, Pashevin D, Goncharov S, Lapikova-Bryhinska T, Lisovyi O, et al. Quercetin is a potential therapy for post-infarction NETosis formation. Naunyn Schmiedebergs Arch Pharmacol. 2025;398:5705. doi:10.1007/s00210-024-03602-w